Animals in the study were fed one of three diets: a very high fat/ no carbohydrate diet; a low-fat/ high carbohydrate diet; and a high fat/ moderate-carbohydrate diet, which is most similar to the “Western” diet most Americans eat, Freedland said. They were then injected with prostate tumors at the same time.
“The mice that were fed a no-carbohydrate diet experienced a 40 to 50 percent prolonged survival over the other mice,” Freedland said.
“We found that carbohydrate restriction without energy restriction – or weight loss – does indeed result in tumor growth delay,” he said.
The researchers plan to begin recruiting patients at two sites – Duke and the University of California – Los Angeles – for a clinical trial to determine if restricting carbohydrate intake in patients with prostate cancer can similarly slow tumor growth. The trial should begin within a few weeks.
“It’s very exciting – this is a potential new mechanism to fight prostate cancer growth and help patients live longer with their disease,” Freedland said.
The findings appear in the May 26, 2009 online edition of the journal Cancer Prevention Research. Funding was provided by the United States Department of Veterans Affairs, the Department of Defense Prostate Cancer Research Program; the American Urological Association/ Foundation Astellas Rising Star in Urology Award, and the Robert C. Atkins Foundation. The Atkins Foundation supported this study but had no additional input or influence on the results.
Other researchers involved in this study include John Mavropoulos, William Buschmeyer, Alok Tewari, Dmitriy Rohkfeld, Phillip Febbo, Gayathri Devi, Eric Westman, Bercedis Peterson and Salvatore Pizzo of Duke; Michael Pollak and Yunhua Zhao of McGill University; Pinchas Cohen and David Hwang of UCLA and Wendy Demark-Wahnefried of the University of Texas – M.D. Anderson Cancer Center.
Adapted from materials provided by Duke University Medical Center.